Article

Adult skull bone marrow is an expanding and resilient hematopoietic reservoir

2023-10-26

Abstract excerpt

<title>Abstract</title> <p>The bone marrow microenvironment is a critical regulator of hematopoietic stem cell self-renewal and fate. While it is appreciated that aging, chronic inflammation and other insults compromise bone marrow function and thereby negatively affect hematopoiesis, it is not known whether different bone compartments exhibit distinct microenvironmental properties and functional resilience. Here...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4a93ddd8-4f2a-5f72-ad46-6af8e4995a36
DOI: 10.21203/rs.3.rs-3426773/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Adult skull bone marrow is an expanding and resilient hematopoietic reservoirDOI 10.21203/rs.3.rs-3426773/v1Read

Changing landscape of hematopoietic and mesenchymal cells and their interactions during aging and in age-related skeletal pathologiesSemantic proximity Read

Vascular Regulation of Hematopoietic Stem Cell Homeostasis, Regeneration, and AgingSemantic proximity Read

The evolving hematopoietic niche during developmentSemantic proximity Read

Interplay Between Skeletal and Hematopoietic Cells in the Bone Marrow Microenvironment in Homeostasis and AgingSemantic proximity Read

Single Cell Resolution Spatial Mapping of Human Hematopoiesis Reveals Aging-Associated Topographic RemodelingSemantic proximity Read

Diversity of Vascular Niches in Bones and Joints During Homeostasis, Ageing, and Diseases.Semantic proximity Read

Hematopoiesis and microenvironment in hematological malignanciesSemantic proximity Read

Megakaryocyte Secreted Factors Regulate Bone Marrow Niche Cells During Skeletal Homeostasis, Aging, and DiseaseSemantic proximity Read

Multi-omics and 3D-imaging reveal bone heterogeneity and unique calvaria cells in neuroinflammationSemantic proximity Read

Single cell transcriptomics identifies a unique adipocyte population that regulates bone marrow environmentSemantic proximity Read

The roles of bone remodeling in normal hematopoiesis and age-related hematological malignanciesSemantic proximity Read

Fundamentals of bone vasculature: Specialization, interactions and functionsSemantic proximity Read