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Article

Dormant cancer cells: programmed quiescence, senescence, or both?

4 Jan 2023

Abstract excerpt

Metastasis is the overwhelming driver of cancer mortality, accounting for the majority of cancer deaths. Many patients present with metastatic relapse years after eradication of the primary lesion. Disseminated cancer cells can undergo a durable proliferative arrest and lie dormant in secondary tissues before reentering the cell cycle to seed these lethal relapses. This process of cancer cell dormancy remains...

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PMID: 36598661
DOI: 10.1007/s10555-022-10073-z

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