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Article

Targeting epiregulin in the treatment-damaged tumor microenvironment restrains therapeutic resistance

6 Oct 2022

Abstract excerpt

The tumor microenvironment (TME) represents a milieu enabling cancer cells to develop malignant properties, while concerted interactions between cancer and stromal cells frequently shape an "activated/reprogramed" niche to accelerate pathological progression. Here we report that a soluble factor epiregulin (EREG) is produced by senescent stromal cells, which non-cell-autonomously develop the senescence-associated...

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PMID: 36202915
DOI: 10.1038/s41388-022-02476-7

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