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Hypoxia-Induced Senescence Drives Immunosuppression in NPC via the MIF-CD74 Axis, an Actionable Therapeutic Target

2026-07-14

Abstract excerpt

<title>Abstract</title> <p>Background Cellular senescence within the hypoxic tumor microenvironment is a key contributor to tumor progression and therapy resistance. However, its specific role and regulatory mechanisms in nasopharyngeal carcinoma(NPC) remain poorly characterized at single-cell resolution. Methods We analyzed single-cell RNA sequencing data from 15 primary NPC tumors using a Computational Senesc...

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Literature Corpus work
b03ee938-9830-5c20-8fb9-154fb877e549
DOI
10.21203/rs.3.rs-9896268/v1
Open publication

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Hypoxia-Induced Senescence Drives Immunosuppression in NPC via the MIF-CD74 Axis, an Actionable Therapeutic TargetDOI 10.21203/rs.3.rs-9896268/v1
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