Article

The cellular basis of mitochondrial stress signaling in the brain

2025-09-16

Abstract excerpt

Neuronal vulnerability to stress is highly cell-type specific, but the underlying mechanisms are poorly understood. Here we show that the ability to activate endoplasmic reticulum (ER) stress signaling is encoded by the relative mitochondrial metabolic activity of neurons. Genetically inducing mitochondrial dysfunction in the Drosophila brain caused the emergence of a novel cluster of neurons, detected using sing...

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Identifiers and source

Literature Corpus work: adc25120-8f10-5473-856b-16a81379381b
DOI: 10.1101/2025.09.11.675336

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