Article
Mitofusin-mediated ER stress triggers neurodegeneration in pink1/parkin models of Parkinson's disease.
Cell death & disease - 23 Jun 2016
Celardo I, Costa A C, Lehmann S, Jones C, Wood N, Mencacci N E, Mallucci G R, Loh S H Y, Martins L M
Abstract excerpt
Mutations in PINK1 and PARKIN cause early-onset Parkinson's disease (PD), thought to be due to mitochondrial toxicity. Here, we show that in Drosophila pink1 and parkin mutants, defective mitochondria also give rise to endoplasmic reticulum (ER) stress signalling, specifically to the activation of the protein kinase R-like endoplasmic reticulum kinase (PERK) branch of the unfolded protein response (UPR). We show...
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