Article

Structural Features of Pathogenic Aggregates Correlate with Cell Pathology in Differentiated Cells

2025-01-14

Abstract excerpt

<title>Abstract</title> <p>The accumulation of intracellular protein aggregates is a hallmark of aging. In hereditary adult-onset neuromuscular diseases (NMDs), these aggregates are not only characteristic but also pathogenic, marking age-related neuromuscular disorders. The transition from age-associated non-pathogenic aggregates to disease-driving pathogenic aggregates remains poorly understood. Poly(A) binding...

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Literature Corpus work: a7f2451c-f308-545b-aa41-6d23c4e54eb1
DOI: 10.21203/rs.3.rs-5676243/v1

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