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Article

A facile assay for zDHHC palmitoyl transferase activation elucidates effects of mutation and modification.

Journal of lipid research - 1 Feb 2025

Adachi Naoko, Hess Douglas T, Ueyama Takehiko

Abstract excerpt

At least 10% of proteins constituting the human proteome are subject to S-acylation by a long-chain fatty acid, thioesterified to a Cys thiol side chain. Fatty S-acylation (prototypically, S-palmitoylation) operates across eukaryotic phylogeny and cell type. S-palmitoylation is carried out in mammalian cells by a family of 23-24 dedicated zDHHC palmitoyl transferase enzymes, and mutation of zDHHCs is associated...

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Identifiers

PMID: 39800157
DOI: 10.1016/j.jlr.2025.100743
PMCID: PMC11870023

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