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Cyclosporin A and FGF signaling support the proliferation/survival of mouse primordial germ cell-like cells in vitro†

20 Oct 2020

Abstract excerpt

Primordial germ cells (PGCs) are the founding population of the germ cell lineage that undergo a multistep process to generate spermatozoa or oocytes. Establishing an appropriate culture system for PGCs is a key challenge in reproductive biology. By a chemical screening using mouse PGC-like cells (mPGCLCs), which were induced from mouse embryonic stem cells, we reported previously that forskolin and rolipram...

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PMID: 33079185
DOI: 10.1093/biolre/ioaa195

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