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Article

MYC and MET cooperatively drive hepatocellular carcinoma with distinct molecular traits and vulnerabilities

24 Nov 2022

Abstract excerpt

Abstract Enhanced activation of the transcription factor MYC and of the receptor tyrosine kinase MET are among the events frequently occurring in hepatocellular carcinoma (HCC). Both genes individually act as drivers of liver cancer initiation and progression. However, their concomitant alteration in HCC has not been explored, nor functionally documented. Here, we analysed databases of five independent human HCC...

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Share to Hepatocellular Carcinoma Treatment and Prognosis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36433941
DOI: 10.1038/s41419-022-05411-6

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