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Article

MYC Deregulation in Primary Human Cancers

25 May 2017

Abstract excerpt

MYC regulates a complex biological program by transcriptionally activating and repressing its numerous target genes. As such, MYC is a master regulator of many processes, including cell cycle entry, ribosome biogenesis, and metabolism. In cancer, the activity of the MYC transcriptional network is frequently deregulated, contributing to the initiation and maintenance of disease. Deregulation often leads to...

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PMID: 28587062
DOI: 10.3390/genes8060151

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