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Article

MYC and therapy resistance in cancer: risks and opportunities

10 Oct 2022

Abstract excerpt

The MYC transcription factor, encoded by the c-MYC proto-oncogene, is activated by growth-promoting signals, and is a key regulator of biosynthetic and metabolic pathways driving cell growth and proliferation. These same processes are deregulated in MYC-driven tumors, where they become critical for cancer cell proliferation and survival. As other oncogenic insults, overexpressed MYC induces a series of cellular...

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PMID: 36214609
DOI: 10.1002/1878-0261.13319

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