Article

Innate Immune Signaling in Hearts and Buccal Mucosa Cells of Patients with Arrhythmogenic Cardiomyopathy

2023-07-27

Abstract excerpt

<h4>STRUCTURED ABSTRACT</h4> <h4>Objectives</h4> We sought to determine if persistent innate immune signaling via NFκB occurs in cardiac myocytes in patients with arrhythmogenic cardiomyopathy and if this is associated with myocardial infiltration of pro-inflammatory cells expressing CCR2. We also determined if buccal mucosa cells from young subjects with inherited disease alleles exhibit NFκB signaling. <h4>Bac...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9feb58f4-2302-5068-bcb2-823d1bdda2a6
DOI: 10.1101/2023.07.25.550526

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Innate Immune Signaling in Hearts and Buccal Mucosa Cells of Patients with Arrhythmogenic CardiomyopathyDOI 10.1101/2023.07.25.550526Read

Mechanisms of Innate Immune Injury in Arrhythmogenic CardiomyopathySemantic proximity Read

Inflammation in Cardiomyopathies: Cellular Mechanisms Across Cardiac Phenotype.Semantic proximity Read

Persistent transcriptional changes in cardiac adaptive immune cells following myocardial infarction: New evidence from the re-analysis of publicly available single cell and nuclei RNA-sequencing data setsSemantic proximity Read

Tissue transcriptomics of endomyocardial biopsies reveals widespread molecular perturbations independent of leukocyte-rich foci in human myocarditisSemantic proximity Read

Myocardial B cells have specific gene expression and predicted interactions in Dilated Cardiomyopathy and Arrhythmogenic Right Ventricular CardiomyopathySemantic proximity Read

Inflammation shapes pathogenesis of murine arrhythmogenic cardiomyopathy.Semantic proximity Read

Characterizing the Molecular Pathology of Arrhythmogenic Cardiomyopathy in Patient Buccal Mucosa Cells.Semantic proximity Read

Inflammation and Immune Response in Arrhythmogenic Cardiomyopathy: State-of-the-Art Review.Semantic proximity Read

Nuclear envelope rupture in cardiomyocytes orchestrates early transcriptomic changes and immune activation in <i>LMNA</i> -related dilated cardiomyopathy that are reversed by LINC complex disruptionSemantic proximity Read

Inflammation and Immunogenetics in Cardiomyopathies: From Molecular Mechanisms to Therapeutic Perspectives.Semantic proximity Read

Spatial transcriptomics unveils ZBTB11 as a regulator of cardiomyocyte degeneration in arrhythmogenic cardiomyopathySemantic proximity Read

Lamin A K97E leads to NF-κB-mediated dysfunction of inflammatory responses in dilated cardiomyopathy.Semantic proximity Read