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Article

Molecular insight into arrhythmogenic cardiomyopathy caused by DSG2 mutations.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Nov 2023

Zhang Baowei, Wu Yizhang, Yang Xingbo, Xiang Yaozu, Yang Bing

Abstract excerpt

Mutant desmoglein 2 (DSG2) is the second most common pathogenic gene in arrhythmogenic cardiomyopathy (ACM), accounting for approximately 10% of ACM cases. In addition to common clinical and pathological features, ACM caused by mutant DSG2 has specific characteristics, manifesting as left ventricle involvement and a high risk of heart failure. Pathological studies have shown extensive cardiomyocyte necrosis,...

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Share to Arrhythmogenic Right Ventricular Dysplasia
Share to Cardiomyopathies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 37696084
DOI: 10.1016/j.biopha.2023.115448

Genes

DSG2

Provenance

PubMed metadata and Literature Corpus relationships.

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