Article

Tissue transcriptomics of endomyocardial biopsies reveals widespread molecular perturbations independent of leukocyte-rich foci in human myocarditis

2025-07-17

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Myocarditis is an inflammatory disease of the myocardium, classically defined and graded by histologic criteria that emphasize immune infiltrates and focal cardiomyocyte injury. The broader transcriptional landscape and intercellular signaling networks underlying human myocarditis, particularly among non-immune cells, remain poorly understood. <h4>Methods</h4> We performed...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8e357a09-b5b3-5430-af70-53d8e0acc85d
DOI: 10.1101/2025.07.11.664335

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tissue transcriptomics of endomyocardial biopsies reveals widespread molecular perturbations independent of leukocyte-rich foci in human myocarditisDOI 10.1101/2025.07.11.664335Read

Spatial transcriptomics reveals layered immune-metabolic architecture of giant cell myocarditisSemantic proximity Read

Persistent transcriptional changes in cardiac adaptive immune cells following myocardial infarction: New evidence from the re-analysis of publicly available single cell and nuclei RNA-sequencing data setsSemantic proximity Read

Immune Transcriptional Signatures Across Human Cardiomyopathy Subtypes: A Multi-Cohort Integrative Computational AnalysisSemantic proximity Read

Spatiotemporal transcriptomics reveals pathogenesis of viral myocarditisSemantic proximity Read

Characterising Shared and Specific Cell–Cell Communication in Cardiomyopathy Subtypes From Single‐Cell Transcriptomics DataSemantic proximity Read

T-cell activation and fibroblastic BMP4-Gremlin dysregulation indicate disease severity in acute myocarditisSemantic proximity Read

Deciphering Immune Complexity: Single-Cell Insights into Autoimmune Myocarditis ProgressionSemantic proximity Read

Targeting Immune-Fibroblast Crosstalk in Myocardial Infarction and Cardiac FibrosisSemantic proximity Read

Myocardial B cells have specific gene expression and predicted interactions in Dilated Cardiomyopathy and Arrhythmogenic Right Ventricular CardiomyopathySemantic proximity Read

Spatial transcriptional landscape of human heart failureSemantic proximity Read

Cardiac SARS-CoV-2 infection is associated with pro-inflammatory transcriptomic alterations within the heartSemantic proximity Read

Cells and gene expression programs in the adult human heartSemantic proximity Read