Article

Phosphorylation-dependent BRD4 dimerization and implications for therapeutic inhibition of BET family proteins

2021-05-14

Abstract excerpt

<title>Abstract</title> <p>Bromodomain-containing protein 4 (BRD4) is an epigenetic reader and oncology drug target that regulates gene transcription through binding to acetylated chromatin via bromodomains (BD). Phosphorylation by casein kinase II (CK2) regulates BRD4 function, is necessary for active transcription and is involved in resistance to BRD4 drug inhibition in triple-negative breast cancer. Here, we p...

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Literature Corpus work: ad172f21-da6d-5a02-a1e2-a3f4145b55ee
DOI: 10.21203/rs.3.rs-519038/v1

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