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Article

BRCT domains: phosphopeptide binding and signaling modules.

Frontiers in bioscience : a journal and virtual library - 1 May 2008

Rodriguez Maria C, Songyang Zhou

Abstract excerpt

The BRCA1 C-terminus (BRCT) domains are essential for the tumor suppressor function of BRCA1, and have been found in a variety of proteins from bacteria to men. Recent studies demonstrate that the BRCT domain constitutes a novel phosphopeptide binding region. In this review we seek to discuss the recent biochemical and structural data that have helped elucidate the molecular basis of BRCT domain function and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18508631
DOI: 10.2741/3125

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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BRCT domains: phosphopeptide binding and signaling modules.PMID 18508631Read ↗

The BRCT domain is a phospho-protein binding domain.Semantic proximity Read ↗

Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains.Semantic proximity Read ↗

Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1.Semantic proximity Read ↗

Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer.Semantic proximity Read ↗

Structural basis of BACH1 phosphopeptide recognition by BRCA1 tandem BRCT domains.Semantic proximity Read ↗

BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligandsSemantic proximity Read ↗

Cancer predisposing mutations in BRCT domains.Semantic proximity Read ↗

Structure of an XRCC1 BRCT domain: a new protein-protein interaction module.Semantic proximity Read ↗

Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1Semantic proximity Read ↗

BRCT Domains: Structure, Functions, and Implications in Disease—New Therapeutic Targets for Innovative Drug Discovery against InfectionsSemantic proximity Read ↗

Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1.Semantic proximity Read ↗

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