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Article

Molecular evolution and the decline of purifying selection with age.

Nature communications - 11 May 2021

Cheng Changde, Kirkpatrick Mark

Abstract excerpt

Life history theory predicts that the intensity of selection declines with age, and this trend should impact how genes expressed at different ages evolve. Here we find consistent relationships between a gene's age of expression and patterns of molecular evolution in two mammals (the human Homo sapiens and the mouse Mus musculus) and two insects (the malaria mosquito Anopheles gambiae and the fruit fly Drosophila...

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Identifiers

PMID: 33976227
DOI: 10.1038/s41467-021-22981-9
PMCID: PMC8113359

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