Article

Benchmarking genome-wide association study causal gene prioritization for drug discovery

2025-09-25

Abstract excerpt

Drug discovery is costly, with billions spent on failed trials. Drugs with genetic support from genome-wide association studies (GWAS) have substantially greater odds of success, but how best to use GWAS to prioritize drug targets remains unclear. We evaluated the performance of GWAS causal gene prioritization methods from the Open Targets consortium by cross-referencing their predictions with drug trial outcomes...

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Literature Corpus work: 98efef94-ab8d-50ef-b5a6-995aaa429ac4
DOI: 10.1101/2025.09.23.25336370

Open publication

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