Article

Selective localization of Mfn2 near PINK1 enable its preferential ubiquitination by Parkin on mitochondria

2021-08-25

Abstract excerpt

Mutations in Parkin and PINK1 cause an early-onset familial Parkinson’s disease. Parkin is a RING-In-Between-RING (RBR) E3 ligase that transfers ubiquitin from an E2 enzyme to a substrate in two steps: 1) thioester intermediate formation on Parkin, and 2) acyl transfer to a substrate lysine. The process is triggered by PINK1, which phosphorylates ubiquitin on damaged mitochondria, which in turn recruits and activa...

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Literature Corpus work: acb69fd7-3826-5b91-9da2-ae421a02b05f
DOI: 10.1101/2021.08.25.457684

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