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How could Parkin-mediated ubiquitination of mitofusin promote mitophagy?

24 Jun 2010

Abstract excerpt

Much evidence links mitochondrial dysfunction to the death of neurons in Parkinson disease (PD), and is particularly emphasized by our growing understanding of the function of genes linked to recessively inherited PD such as PINK1, parkin and DJ-1. Recent work has revealed an exciting link between the PINK1-Parkin pathway and the autophagic turnover of dysfunctional mitochondrial (mitophagy). We have recently...

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PMID: 20484985
DOI: 10.4161/auto.6.5.12242

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How could Parkin-mediated ubiquitination of mitofusin promote mitophagy?PMID 20484985Read ↗

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