Article

E2 ubiquitin conjugase Bendless is essential for PINK1-Park activity to regulate Mitofusin under mitochondrial stress

2022-10-24

Abstract excerpt

Cells under mitochondrial stress often co-opt mechanisms to maintain energy homeostasis, mitochondrial quality control and cell survival. A mechanistic understanding of such responses is crucial for further insight into mitochondrial biology and diseases. Through an unbiased genetic screen in Drosophila , we identify that mutations in lrpprc2 , a homolog of the human LRPPRC gene that is linked to the French-Can...

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Literature Corpus work: 748663e2-0afb-5b23-8f54-a435788a5287
DOI: 10.1101/2022.10.24.513457

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