Article

A substrate-interacting region of Parkin directs ubiquitination of the mitochondrial GTPase Miro1

2024-06-03

Abstract excerpt

Mutations in the gene encoding for the E3 ubiquitin ligase Parkin have been linked to early-onset Parkinson’s disease. Besides many other cellular roles, Parkin is involved in clearance of damaged mitochondria via mitophagy - a process of particular importance in dopaminergic neurons. Upon mitochondrial damage, Parkin accumulates at the outer mitochondrial membrane and is activated, leading to ubiquitination of ma...

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Literature Corpus work: f967c6e7-9941-5716-9e33-f998c4277ccc
DOI: 10.1101/2024.06.03.597144

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