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Article

A substrate-interacting region of Parkin directs ubiquitination of the mitochondrial GTPase Miro1

14 May 2025

Abstract excerpt

Mutations in the E3 ubiquitin ligase Parkin gene have been linked to early onset Parkinson's disease. Besides many other roles, Parkin is involved in clearance of damaged mitochondria via mitophagy-a process of particular importance in dopaminergic neurons. Upon mitochondrial damage, Parkin accumulates at the outer mitochondrial membrane and is activated, leading to ubiquitination of many mitochondrial substrates...

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Share to Autophagy in Disease and Therapy
Share to Parkinson's Disease Mechanisms and Treatments
Share to Ubiquitin and proteasome pathways

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Identifiers

PMID: 40576561
DOI: 10.1083/jcb.202408025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

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Research trail→

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A substrate-interacting region of Parkin directs ubiquitination of the mitochondrial GTPase Miro1PMID 40576561Read ↗

A substrate-interacting region of Parkin directs ubiquitination of the mitochondrial GTPase Miro1Semantic proximity Read ↗

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A Ubl/ubiquitin switch in the activation of ParkinSemantic proximity Read ↗

Parkin ubiquitinates Drp1 for proteasome-dependent degradation: implication of dysregulated mitochondrial dynamics in Parkinson disease.Semantic proximity Read ↗

Parkin promotes the ubiquitination and degradation of the mitochondrial fusion factor mitofusin 1.Semantic proximity Read ↗

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Parkin uses the UPS to ship off dysfunctional mitochondriaSemantic proximity Read ↗

Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation.Semantic proximity Read ↗

Identification of deubiquitylases involved in Parkin-mediated mitophagySemantic proximity Read ↗

Select E2 enzymes differentially regulate parkin activation and mitophagySemantic proximity Read ↗

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