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Engineering a Cell-Based Orthogonal Ubiquitin Transfer Cascade for Profiling the Substrates of RBR E3 Parkin

2024-09-15

Abstract excerpt

The E3 ubiquitin (UB) ligase Parkin utilizes a Ring-Between-Ring (RBR) domain to mediate the transfer of UB to its substrates to regulate diverse cellular functions, including mitochondrial quality control, cell cycle progression, metabolism programming, and the establishment of synaptic functions. Mutations affecting the E3 ligase activity of Parkin are associated with cancer and Parkinson’s disease (PD). An esse...

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Literature Corpus work
d33ea6de-7045-5947-8abc-1ee6c61729c9
DOI
10.1101/2024.09.14.613079
Open publication

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Engineering a Cell-Based Orthogonal Ubiquitin Transfer Cascade for Profiling the Substrates of RBR E3 ParkinDOI 10.1101/2024.09.14.613079
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