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Retrotransposon-derived transcripts and their functions in immunity and disease

1 Dec 2023

Abstract excerpt

Retrotransposons, which account for approximately 42% of the human genome, have been increasingly recognized as "non-self" pathogen-associated molecular patterns (PAMPs) due to their virus-like sequences. In abnormal conditions such as cancer and viral infections, retrotransposons that are aberrantly expressed due to impaired epigenetic suppression display PAMPs, leading to their recognition by pattern...

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PMID: 38199240
DOI: 10.1266/ggs.23-00187

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