Article

Repeats Mimic Pathogen-Associated Patterns Across a Vast Evolutionary Landscape

2021-11-04

Abstract excerpt

<h4>ABSTRACT</h4> An emerging hallmark across human diseases – such as cancer, autoimmune and neurodegenerative disorders – is the aberrant transcription of typically silenced repetitive elements. Once active, a subset of repeats may be capable of “viral mimicry”: the display of pathogen-associated molecular patterns (PAMPs) that can, in principle, bind pattern recognition receptors (PRRs) of the innate immune sy...

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Literature Corpus work: ab681397-e653-5961-b1fc-41e7ecf00f12
DOI: 10.1101/2021.11.04.467016

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