Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Global Cancer Transcriptome Quantifies Repeat Element Polarization between Immunotherapy Responsive and T Cell Suppressive Classes

1 Apr 2018

Abstract excerpt

It has been posited that anti-tumoral innate activation is driven by derepression of endogenous repeats. We compared RNA sequencing protocols to assess repeat transcriptomes in The Cancer Genome Atlas (TCGA). Although poly(A) selection efficiently detects coding genes, most non-coding genes, and limited subsets of repeats, it fails to capture overall repeat expression and co-expression. Alternatively, total RNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Immunotherapy and Biomarkers
Share to RNA modifications and cancer
Share to Single-cell and spatial transcriptomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29642008
DOI: 10.1016/j.celrep.2018.03.042

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Global Cancer Transcriptome Quantifies Repeat Element Polarization between Immunotherapy Responsive and T Cell Suppressive ClassesPMID 29642008Read ↗

Global Cancer Transcriptome Quantifies Repeat Element Polarization Between Immunotherapy Responsive and T cell Suppressive ClassesSemantic proximity Read ↗

Satellite repeat RNA expression in epithelial ovarian cancer associates with a tumor-immunosuppressive phenotype.Semantic proximity Read ↗

Cancer cells co-evolve with retrotransposons to mitigate viral mimicrySemantic proximity Read ↗

PERREO: An integrated pipeline for repetitive elements analysis enables the repeatome expression profiling in cancerSemantic proximity Read ↗

Transcriptomic splicing analysis reveals a gene-independent form of TE reactivation in tumors representing unrecognized source of oncogenes and neoantigensSemantic proximity Read ↗

A common set of structurally distinct endogenous retroviruses predict survival in multiple human tumor typesSemantic proximity Read ↗

The contribution of uncharted RNA sequences to tumor identity in lung adenocarcinomaSemantic proximity Read ↗

Single Cell Spatial Transcriptomic Profiling Identifies a LINE1 Associated Disarrayed Immune Microenvironment in Hepatocellular CarcinomaSemantic proximity Read ↗

Proteomic and Genomic Signatures of Repeat-instability in Cancer and Adjacent Normal TissuesSemantic proximity Read ↗

Exosomes transmit retroelement RNAs to drive inflammation and immunosuppression in Ewing SarcomaSemantic proximity Read ↗

Retroelement co-option disrupts the cancer transcriptional programmeSemantic proximity Read ↗

Genetic and immunologic features of recurrent stage I lung adenocarcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.