Article

Characterization of human Metaxin proteins reveals functional diversification of SAM37 homologs MTX1 and MTX3

2026-03-17

Abstract excerpt

The biogenesis of outer mitochondrial membrane β-barrel proteins relies on the mitochondrial Sorting and Assembly Machinery (SAM) complex. In humans, the SAM complex contains SAM50 along with Metaxin (MTX) accessory subunits. MTX1 and MTX3 are homologous yet their functional similarities and differences have scarcely been investigated. Homozygous null mutations in the MTX2 gene are linked to a rare progeroid synd...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ac763a76-072f-561b-baae-9d8bd9cdcecd
DOI: 10.64898/2026.03.15.711473

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Characterization of human Metaxin proteins reveals functional diversification of SAM37 homologs MTX1 and MTX3DOI 10.64898/2026.03.15.711473Read

Loss of MTX2 causes mandibuloacral dysplasia and links mitochondrial dysfunction to altered nuclear morphology.Semantic proximity Read

<i>Drosophila</i> Metaxin-2 controls beta-barrel protein biogenesis and muscle growth in a stage-dependent fashionSemantic proximity Read

Ablation of <i>Sam50</i> is associated with fragmentation and alterations in metabolism in murine and human myotubesSemantic proximity Read

SLC25A46 is in contact with lysosomes and plays a role in mitochondrial cholesterol homeostasisSemantic proximity Read

The TIM22 complex mediates the import of sideroflexins and is required for efficient mitochondrial one-carbon metabolism.Semantic proximity Read

A X-linked nonsense APOO/MIC26 variant causes a lethal mitochondrial disease with progeria-like phenotypes.Semantic proximity Read

The morphology proteins Mdm12/Mmm1 function in the major beta-barrel assembly pathway of mitochondria.Semantic proximity Read

MTCH2 is a mitochondrial outer membrane protein insertaseSemantic proximity Read

Mitochondrial membrane proteins and VPS35 orchestrate selective removal of mtDNASemantic proximity Read

Conserved GxxxG and WN motifs of MIC13 are essential for bridging two MICOS subcomplexes.Semantic proximity Read

Mrx6 binds the Lon protease Pim1 N-terminal domain to confer selective substrate specificity and regulate mtDNA copy number.Semantic proximity Read

The mitochondrial morphology protein Mdm10 functions in assembly of the preprotein translocase of the outer membrane.Semantic proximity Read