Article

<i>Drosophila</i> Metaxin-2 controls beta-barrel protein biogenesis and muscle growth in a stage-dependent fashion

2025-05-27

Abstract excerpt

Metaxin-2 (Mtx2) is an evolutionarily conserved mitochondrial outer membrane protein. Mutations in human Mtx2 cause mandibuloacral dysplasia (MADaM), a progeroid disorder. However, the pathologic mechanisms of Mtx2 loss-of-function remain largely unknown. Using Drosophila , we show Mtx2 null mutants exhibit pupal lethality, rescued by Drosophila or human Mtx2, underscoring functional conservation across speci...

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Literature Corpus work: 603dd66c-4661-5f41-a758-28f5376b87ee
DOI: 10.1101/2025.05.22.655489

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<i>Drosophila</i> Metaxin-2 controls beta-barrel protein biogenesis and muscle growth in a stage-dependent fashionDOI 10.1101/2025.05.22.655489Read

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