Article

Mitochondrial membrane proteins and VPS35 orchestrate selective removal of mtDNA

2021-08-06

Abstract excerpt

Integrity of mitochondrial DNA (mtDNA), encoding several subunits of the respiratory chain, is essential to maintain mitochondrial fitness. Mitochondria, as a central hub for metabolism, are affected in a wide variety of human diseases but also during normal ageing, where mtDNA integrity is compromised. Mitochondrial quality control mechanisms work at different levels, and mitophagy and its variants are critical t...

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Literature Corpus work: c96bb936-9c86-50c0-b1ea-31010ba38faf
DOI: 10.1101/2021.08.06.455397

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