Article
The mitochondrial morphology protein Mdm10 functions in assembly of the preprotein translocase of the outer membrane.
Developmental cell - 1 Jul 2004
Meisinger Chris, Rissler Michael, Chacinska Agnieszka, Szklarz Luiza K Sanjuán, Milenkovic Dusanka, Kozjak Vera, Schönfisch Birgit, Lohaus Christiane, Meyer Helmut E, Yaffe Michael P, Guiard Bernard, Wiedemann Nils, Pfanner Nikolaus
Abstract excerpt
The biogenesis of mitochondrial outer membrane proteins involves the general translocase of the outer membrane (TOM complex) and the sorting and assembly machinery (SAM complex). The two known subunits of the SAM complex, Mas37 and Sam50, are required for assembly of the abundant outer membrane proteins porin and Tom40. We have identified an unexpected subunit of the SAM complex, Mdm10, which is involved in...
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