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Article

Mrx6 binds the Lon protease Pim1 N-terminal domain to confer selective substrate specificity and regulate mtDNA copy number.

Nucleic acids research - 14 Jan 2026

Schrott Simon, Marafelli Ilaria, Gerle Charlotte, Bibinger Sebastian, Bertgen Lea, Marino Giada, Schwenkert Serena, Rathberger Romina, Herrmann Johannes M, Osman Christof

Abstract excerpt

Mitochondrial DNA (mtDNA) copy number regulation remains incompletely understood, despite its importance in cellular function. In Saccharomyces cerevisiae, Mrx6 belongs to the Pet20-domain-containing protein family, consisting of Mrx6, Pet20, and Sue1. Notably, absence of Mrx6 leads to increased mtDNA copy number. Here, we identify the C-terminus of Mrx6 as essential for its stability and interaction with the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41533588
DOI: 10.1093/nar/gkaf1390
PMCID: PMC12802967

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