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Article

The complex genetic architecture of Alzheimer's disease: novel insights and future directions.

EBioMedicine - 1 Apr 2023

Andrews Shea J, Renton Alan E, Fulton-Howard Brian, Podlesny-Drabiniok Anna, Marcora Edoardo, Goate Alison M

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) is a complex multifactorial neurodegenerative disorder and the most common form of dementia. AD is highly heritable, with heritability estimates of ∼70% from twin studies. Progressively larger genome-wide association studies (GWAS) have continued to expand our knowledge of AD/dementia genetic architecture. Until recently these efforts had identified 39 disease susceptibility...

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Identifiers

PMID: 36907103
DOI: 10.1016/j.ebiom.2023.104511
PMCID: PMC10024184

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