Article
Linking genomic and proteomic signatures to brain amyloid burden: insights from GR@ACE/DEGESCO.
Functional & integrative genomics - 25 Mar 2025
Puerta Raquel, de Rojas Itziar, García-González Pablo, Olivé Clàudia, Sotolongo-Grau Oscar, García-Sánchez Ainhoa, García-Gutiérrez Fernando, Montrreal Laura, Tartari Juan Pablo, Sanabria Ángela, Pytel Vanesa, Lage Carmen, Quintela Inés, Aguilera Nuria, Rodriguez-Rodriguez Eloy, Alarcón-Martín Emilio, Orellana Adelina, Pastor Pau, Pérez-Tur Jordi, Piñol-Ripoll Gerard, López de Munain Adolfo, García-Alberca Jose María, Royo Jose Luís, Bullido María J, Álvarez Victoria, Real Luis Miguel, Corbatón Anchuelo Arturo, Gómez-Garre Dulcenombre, Martínez Larrad María Teresa, Franco-Macías Emilio, Mir Pablo, Medina Miguel, Sánchez-Valle Raquel, Dols-Icardo Oriol, Sáez María Eugenia, Carracedo Ángel, Tárraga Lluís, Alegret Montse, Valero Sergi, Marquié Marta, Boada Mercè, Sánchez Juan Pascual, Cavazos Jose Enrique, Cabrera-Socorro Alfredo, Cano Amanda, Ruiz Agustín
Abstract excerpt
Alzheimer's disease (AD) is a complex disease with a strong genetic component, yet many genetic risk factors remain unknown. We combined genome-wide association studies (GWAS) on amyloid endophenotypes measured in cerebrospinal fluid (CSF) and positron emission tomography (PET) as surrogates of amyloid pathology, which may provide insights into the underlying biology of the disease. We performed a meta-GWAS of...
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