Article
Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease.
Nature - 20 May 1999
Ona V O, Li M, Vonsattel J P, Andrews L J, Khan S Q, Chung W M, Frey A S, Menon A S, Li X J, Stieg P E, Yuan J, Penney J B, Young A B, Cha J H, Friedlander R M
Abstract excerpt
Huntington's disease is an autosomal-dominant progressive neurodegenerative disorder resulting in specific neuronal loss and dysfunction in the striatum and cortex. The disease is universally fatal, with a mean survival following onset of 15-20 years and, at present, there is no effective treatme...
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