Article

Single-domain antibodies for targeting, detection and <i>in vivo</i> imaging of human CD4 <sup>+</sup> cells

2021-07-04

Abstract excerpt

The advancement of new immunotherapies necessitates appropriate probes to monitor the presence and distribution of distinct immune cell populations. Considering the key role of CD4 + T cells in regulating immunological processes, we generated novel single-domain antibodies (nanobodies, Nbs) that specifically recognize human CD4. After in depth analysis of their binding properties, recognized epitopes, and effects...

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Literature Corpus work: ac34f2d6-d281-5eeb-aea2-a7181ce90645
DOI: 10.1101/2021.07.02.450848

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