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Article

Engineered antibody fragments for immuno-PET imaging of endogenous CD8+ T cells in vivo.

Proceedings of the National Academy of Sciences of the United States of America - 21 Jan 2014

Tavaré Richard, McCracken Melissa N, Zettlitz Kirstin A, Knowles Scott M, Salazar Felix B, Olafsen Tove, Witte Owen N, Wu Anna M

Abstract excerpt

The noninvasive detection and quantification of CD8(+) T cells in vivo are important for both the detection and staging of CD8(+) lymphomas and for the monitoring of successful cancer immunotherapies, such as adoptive cell transfer and antibody-based immunotherapeutics. Here, antibody fragments are constructed to target murine CD8 to obtain rapid, high-contrast immuno-positron emission tomography (immuno-PET)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24390540
DOI: 10.1073/pnas.1316922111
PMCID: PMC3903195

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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