Article

Decoding frontotemporal and cell type-specific vulnerabilities to neuropsychiatric disorders and psychoactive drugs

2022-12-01

Abstract excerpt

Abnormalities in temporal and frontal lobes (TL and FL) have been linked to cognition and neuropsychiatric disorders. While structural and functional differences between the brain lobes have been documented in disease, the cellular heterogeneity in FL and TL and its impact to the vulnerability to genetic risk factors for neuropsychiatric disorders is not well studied. We hypothesize that intrinsic cellular-level d...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ac293bbb-2dbb-5add-a3f4-026b06729c01
DOI: 10.1101/2022.11.30.518630

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Decoding frontotemporal and cell type-specific vulnerabilities to neuropsychiatric disorders and psychoactive drugsDOI 10.1101/2022.11.30.518630Read

Decoding frontotemporal and cell-type-specific vulnerabilities to neuropsychiatric disorders and psychoactive drugs.Semantic proximity Read

Contrasting genetic predisposition and diagnosis in psychiatric disorders: a multi-omic single-nucleus analysis of the human orbitofrontal cortexSemantic proximity Read

Single-nucleus transcriptome analysis reveals cell type-specific molecular signatures across reward circuitry in the human brainSemantic proximity Read

Single-nuclei transcriptomics of schizophrenia prefrontal cortex primarily implicates neuronal subtypesSemantic proximity Read

Single-nucleus transcriptomics identifies a shared vulnerable excitatory neuronal population across typical and atypical Alzheimer’s diseaseSemantic proximity Read

Comprehensive analyses of RNA-seq and genome-wide data point to enrichment of neuronal cell type subsets in neuropsychiatric disordersSemantic proximity Read

Compensatory Plasticity Defines a Vulnerable Neuronal State in Alzheimer’s Disease with PsychosisSemantic proximity Read

Genetic Identification of Cell Types Underlying Brain Complex Traits Yields Novel Insights Into the Etiology of Parkinson’s DiseaseSemantic proximity Read

Single-cell dissection of schizophrenia reveals neurodevelopmental-synaptic axis and transcriptional resilienceSemantic proximity Read

Multiregional single-cell profiling reveals shared and specialized cellular vulnerability in Alzheimer’s diseaseSemantic proximity Read

Transcriptional Patterns in Stages of Alzheimer's Disease Are Cell-Type–Specific and Partially Converge with the Effects of Alcohol Use Disorder in HumansSemantic proximity Read

Single-cell profiling of the human primary motor cortex in ALS and FTLDSemantic proximity Read