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Article

Decoding frontotemporal and cell-type-specific vulnerabilities to neuropsychiatric disorders and psychoactive drugs.

Open biology - 1 Jun 2024

Ji Jiatong, Chao Honglu, Chen Huimei, Liao Jun, Shi Wenqian, Ye Yangfan, Wang Tian, You Yongping, Liu Ning, Ji Jing, Petretto Enrico

Abstract excerpt

Frontotemporal lobe abnormalities are linked to neuropsychiatric disorders and cognition, but the role of cellular heterogeneity between temporal lobe (TL) and frontal lobe (FL) in the vulnerability to genetic risk factors remains to be elucidated. We integrated single-nucleus transcriptome analysis in 'fresh' human FL and TL with genetic susceptibility, gene dysregulation in neuropsychiatric disease and...

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Source

Open in PubMed Open full text

Identifiers

PMID: 38864245
DOI: 10.1098/rsob.240063
PMCID: PMC11285532

Genes

PVALB
GRIN2A
SLC12A5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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