Article
Losing Dnmt3a dependent methylation in inhibitory neurons impairs neural function by a mechanism impacting Rett syndrome.
eLife - 11 Mar 2020
Lavery Laura A, Ure Kerstin, Wan Ying-Wooi, Luo Chongyuan, Trostle Alexander J, Wang Wei, Jin Haijing, Lopez Joanna, Lucero Jacinta, Durham Mark A, Castanon Rosa, Nery Joseph R, Liu Zhandong, Goodell Margaret, Ecker Joseph R, Behrens M Margarita, Zoghbi Huda Y
Abstract excerpt
Methylated cytosine is an effector of epigenetic gene regulation. In the brain, Dnmt3a is the sole 'writer' of atypical non-CpG methylation (mCH), and MeCP2 is the only known 'reader' for mCH. We asked if MeCP2 is the sole reader for Dnmt3a dependent methylation by comparing mice lacking either protein in GABAergic inhibitory neurons. Loss of either protein causes overlapping and distinct features from the...
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