Article
Intellectual and Developmental Disabilities Research Centers: A Multidisciplinary Approach to Understand the Pathogenesis of Methyl-CpG Binding Protein 2-related Disorders.
Neuroscience - 1 Oct 2020
Fagiolini Michela, Patrizi Annarita, LeBlanc Jocelyn, Jin Lee-Way, Maezawa Izumi, Sinnett Sarah, Gray Steven J, Molholm Sophie, Foxe John J, Johnston Michael V, Naidu Sakkubai, Blue Mary, Hossain Ahamed, Kadam Shilpa, Zhao Xinyu, Chang Quiang, Zhou Zhaolan, Zoghbi Huda
Abstract excerpt
Disruptions in the gene encoding methyl-CpG binding protein 2 (MECP2) underlie complex neurodevelopmental disorders including Rett Syndrome (RTT), MECP2 duplication disorder, intellectual disabilities, and autism. Significant progress has been made on the molecular and cellular basis of MECP2-related disorders providing a new framework for understanding how altered epigenetic landscape can derail the formation...
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