Article

Interaction of PINK1 with nucleotides and kinetin

2023-08-09

Abstract excerpt

PINK1 is a ubiquitin kinase that accumulates on damaged mitochondria to trigger mitophagy, and PINK1 loss-of-function mutations cause early onset Parkinson’s disease. Nucleotide analogues such as kinetin triphosphate (KTP) have been suggested to enhance PINK1 activity and may represent a therapeutic strategy for the treatment of Parkinson’s disease. Here, we investigate the interaction of PINK1 with nucleotides, i...

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Literature Corpus work: abeee2b4-c9da-5a60-830b-5b59cbab8d01
DOI: 10.1101/2023.08.08.552531

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