Article

Identifying causal brain structures and proteins for osteoarthritis: A large-scale genetic correlation study based on brain imaging-derived phenotypes, transcriptome and proteome

2024-01-31

Abstract excerpt

<title>Abstract</title> <p>This study aimed to validate the causal associations of brain structures with osteoarthritis (OA) and then describe key causal genes and proteins in brain related to OA risk.<bold> </bold>To explore the genetic correlation and causal relationship between brain structures and OA, linkage disequilibrium score regression (LDSC) and mendelian randomization (MR) were employed. Then a transcr...

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Literature Corpus work: abeb41ce-631e-5b31-84c9-a9abc058de1e
DOI: 10.21203/rs.3.rs-3863182/v1

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