The role of the brain-bone axis in skeletal degenerative diseases and psychiatric disorders, A genome-wide pleiotropic analysis.

doi:10.1016/j.pnpbp.2025.111388

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Article

The role of the brain-bone axis in skeletal degenerative diseases and psychiatric disorders, A genome-wide pleiotropic analysis.

Progress in neuro-psychopharmacology & biological psychiatry - 20 Jun 2025

Gao Shang, Qi Lijie, Li Nianhu, Li Xin, Zhang Jie, Zhang Zhaoqi, Liu Wei

Abstract excerpt

INTRODUCTION: Skeletal degenerative diseases and psychiatric disorders often coexist clinically. However, the genetic correlations and underlying biological mechanisms between these two types of diseases remain unclear. OBJECTIVES: To investigate the genetic correlations between skeletal degenerative diseases and psychiatric disorders and to identify shared genomic loci, genes, and pathways. METHODS: This...

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Topics

Humans
Genome-Wide Association Study
Genetic Pleiotropy
Mental Disorders
Intervertebral Disc Degeneration
Brain

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mendelian Randomization Analysis

Schizophrenia

Osteoarthritis

Bone and Bones

Osteoporosis

Major Depressive Disorder

Genetic Predisposition to Disease

Source

Open in PubMed

Identifiers

PMID: 40340016
DOI: 10.1016/j.pnpbp.2025.111388

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