Article
Identifying Causal Brain Structures, Genes, and Proteins for Osteoarthritis: A Large-Scale Genetic Correlation Study Based on Brain Imaging-Derived Phenotypes, Transcriptomes, and Proteomes.
The journals of gerontology. Series A, Biological sciences and medical sciences - 10 Jun 2025
Wang Chao, Liu Zhi, Zhu Yong, Ruan Zhe, Long Haitao, Lin Zhangyuan, Zhao Ruibo, Xiao Wenfeng, Li Yusheng, Zhao Shushan
Abstract excerpt
BACKGROUND: Recent epidemiological studies have linked the central nervous system (CNS) to osteoarthritis (OA), suggesting that targeting the CNS could offer new therapeutic strategies. This study aimed to validate the correlation between brain structures and OA risk, and to identify key causal genes by integrating brain transcriptomic and proteomic data with OA genome-wide association studies (GWAS). METHODS: We...
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