Back to search

Article

A ‘brain-first’ mouse model of progressive alpha-synuclein pathology via intranasal rotenone administration

2025-10-12

Abstract excerpt

The precise aetiology of Parkinson’s disease (PD) is still poorly understood, but it is thought to arise due to an intricate relationship between genes and the environment. Our study takes a unique approach to understanding the effect of environmental factors on the onset and progression of α-synuclein (aSyn) pathology, a key feature of PD, from the olfactory bulb (OB) to other brain regions. In the present study,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
abe3d69c-56e9-57fe-a3c6-4df207966fb2
DOI
10.1101/2025.10.10.677764
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A ‘brain-first’ mouse model of progressive alpha-synuclein pathology via intranasal rotenone administrationDOI 10.1101/2025.10.10.677764
Silent Spread: Olfactory Bulb α-Synuclein Seeding in Wild-Type Mice Drives Pathology and Transient Neuroinflammation While Sparing FunctionSemantic proximity
Alpha-synuclein pathology and Parkinson’s disease-related olfactory dysfunctions: an update on preclinical models and therapeutic approachesSemantic proximity
Olfactory neuron-specific expression of A30P α-synuclein exacerbates dopamine deficiency and hyperactivity in a novel conditional model of early Parkinson's disease stages.Semantic proximity
Environmental neurotoxic challenge of conditional alpha-synuclein transgenic mice predicts a dopaminergic olfactory-striatal interplay in early PD.Semantic proximity
α-Synuclein in the olfactory system of a mouse model of Parkinson's disease: correlation with olfactory projections.Semantic proximity
Intranigral injection of Alpha-Synuclein pre-formed fibrils leads to BBB compromise and Bilateral Dopaminergic Neurodegeneration in A53T Alpha-Synuclein transgenic miceSemantic proximity
Development and characterisation of a novel rat model of Parkinson's disease induced by sequential intranigral administration of AAV-α-synuclein and the pesticide, rotenoneSemantic proximity
A new synuclein-transgenic mouse model for early Parkinson’s reveals molecular features of preclinical diseaseSemantic proximity
Alpha‐synuclein at the nexus of genes and environment: the impact of environmental enrichment and stress on brain health and diseaseSemantic proximity
Phosphorylation and Truncation of α-Synuclein do not trigger Parkinsonian Readouts in A53T-SNCA MiceSemantic proximity
Early start of progressive motor deficits in Line 61 α-synuclein transgenic miceSemantic proximity
Sex specific effects of environmental toxin-derived alpha synuclein on enteric neuronal-epithelial interactionsSemantic proximity
Select a neighboring publication to make it the new centre.