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Article

Environmental neurotoxic challenge of conditional alpha-synuclein transgenic mice predicts a dopaminergic olfactory-striatal interplay in early PD.

Acta neuropathologica - 1 Apr 2014

Nuber Silke, Tadros Daniel, Fields Jerel, Overk Cassia Rose, Ettle Benjamin, Kosberg Kori, Mante Michael, Rockenstein Edward, Trejo Margarita, Masliah Eliezer

Abstract excerpt

The olfactory bulb (OB) is one of the first brain regions in Parkinson's disease (PD) to contain alpha-synuclein (α-syn) inclusions, possibly associated with nonmotor symptoms. Mechanisms underlying olfactory synucleinopathy, its contribution to progressive aggregation pathology and nigrostriatal dopaminergic loss observed at later stages, remain unclear. A second hit, such as environmental toxins, is suggestive...

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Identifiers

PMID: 24509835
DOI: 10.1007/s00401-014-1255-5
PMCID: PMC4324760

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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