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Article

α-Synuclein in the olfactory system of a mouse model of Parkinson's disease: correlation with olfactory projections.

Brain structure & function - 1 Apr 2012

Ubeda-Bañon Isabel, Saiz-Sanchez Daniel, de la Rosa-Prieto Carlos, Martinez-Marcos Alino

Abstract excerpt

Olfactory deficits are an early feature of Parkinson's disease (PD). Neuropathologically, α-synucleinopathy (Lewy bodies and neurites) is observed earlier (stage 1) in the olfactory system than in the substantia nigra (stage 3), and this could underlies the early olfactory symptoms. In the present report, we analyzed the distribution of α-synuclein deposits in tertiary olfactory structures (anterior olfactory...

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PMID: 21928152
DOI: 10.1007/s00429-011-0347-4

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