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Silent Spread: Olfactory Bulb α-Synuclein Seeding in Wild-Type Mice Drives Pathology and Transient Neuroinflammation While Sparing Function

2026-08-19

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<title>Abstract</title> <p> Olfactory dysfunction is among the earliest non-motor symptoms of Parkinson’s disease, prompting the development of preclinical models that target the olfactory system to investigate the onset and spread of α-Synuclein (α-Syn) pathology. Here, we conducted a comprehensive longitudinal characterization of an olfactory bulb α-Syn preformed fibril (PFF) seeding model in wild-type C57BL/6...

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Literature Corpus work
29661103-38e3-5071-9f99-c0a550bdf226
DOI
10.21203/rs.3.rs-10656575/v1
Open publication

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Silent Spread: Olfactory Bulb α-Synuclein Seeding in Wild-Type Mice Drives Pathology and Transient Neuroinflammation While Sparing FunctionDOI 10.21203/rs.3.rs-10656575/v1
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